Biointeractive The Eukaryotic Cell Cycle And Cancer
Question: Unicellular
Answer: only way to reproduce
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Question: Mulitcellular
Answer: Replaces dead or damaged cells and more than one way to reproduce
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Question: Why is cell division important to an adult organism?
Answer: Skin + Digestive system cells are continuously renewed
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Question: What is the role of growth factors?
Answer: It signals cell division
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Question: What is differentiation ?
Answer: Differentiation is when a cell receives other signal from other nucleuses
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Question: What are cell cycle regulators?
Answer: Cyclin-Dependent Kinase. Through phosphorylation
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Question: Where does cell division occur?
Answer: Meiosis for sex cells and Mitosis for body cells
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Question: Where does cell differentiation occur?
Answer: Crypt-Right after moving into the lumen
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Question: Where does apoptosis occur?
Answer: Top of the villi/peak
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Question: What is one harmless result of too little cell division?
Answer: Hair loss
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Question: What is one harmless result of too much cell division?
Answer: Warts
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Question: List in order the Cell Cycle phases
Answer: 1. G1 2. S 3. G2 4.M
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Question: What is G1 in the Cell Cycle?
Answer: G1-Gap1 and is the first checkpoint and its job is cell division.
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Question: What is S in the Cell Cycle?
Answer: S-Synthesis it is the second checkpoint and its job is to make sure there are no errors
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Question: What is G2 in the Cell Cycle?
Answer: G2-Gap2 and it is checkpoint 3 and its purpose is to make sure the DNA is intact
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Question: What is M in the cell cycle?
Answer: M-Mitosis it is the fourth checkpoint(final checkpoint) its purpose is to make sure the chromosomes are unattached
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Question: What is the purpose of a checkpoint during the cell cycle?
Answer: To ensure proper division of the cell
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Question: What is one potential outcome when error occur in the cell cycle?
Answer: The cell can mutate
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Question: What is the type of protein that regulates the cell cycle is encoded by proto-oncogenes?
Answer: APC/C
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Question: What type of protein that regulates the tumor suppressor genes?
Answer: p53
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Question: What are the most important cell cycle regulators?
Answer: CDK's-Cyclin-Independent Kinases
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Question: What is a kinase?
Answer: Enzymes that add phosphate to other proteins.
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Question: When are cyclins present inside the cell during cell cycle?
Answer: Cyclin is only active when the cyclin is attached to CDK
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Question: What do active CDK's do?
Answer: Regulate how the time of each phase
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Question: What are the phase events for G1 ?
Answer: Increase in size
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Question: What are the phase events for S/Synthesis?
Answer: Replicate the Dna
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Question: What are the phase events for G2?
Answer: Organelles duplicate
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Question: What are the phase events for M/Mitosis?
Answer: Two daughter cells
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Question: What are the Regulatory Process for G1?
Answer: CDK,p53,and RB
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Question: What are the Regulatory process for S?
Answer: CDK and BRCA 1
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Question: What are the Regulatory process for G2?
Answer: CDK and p53
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Question: What are the Regulatory process for M?
Answer: apc/c and mad
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Question: What is the GO phase in the cell cycle?
Answer: The cell doesn't divide
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Question: What is and example of a cell that is permanently in GO?
Answer: Neurons and Muscle cells.
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Question: What is and example of a cell that can leave GO to go through the cell cycle again?
Answer: Liver cells
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Question: Name two reasons why cells can form tumors?
Answer: Too much cell division and too little cell death
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Question: What causes uncontrolled cell division?
Answer: Mutations of proteins that regulate the cell cycle
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Question: What occurs if the apc gene is mutated?
Answer: They don't differentiate into epithelial cells in the lumen
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Question: What do mutated proto-oncogenes do?
Answer: They cause the cell cycle to speed up
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Question: What do mutated tumor suppressor genes do?
Answer: They deregulate the cell cycle
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Question: What do proto-oncogene need to cause cancer?
Answer: Proto-oncogenes require 1 allele to be mutated to be considered dominant. In the results there is a gain in the function.
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Question: What do tumor suppressor genes need to cause cancer?
Answer: they need 2 alleles to be mutated to be considered recessive in the results there is a loss in the function.
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Question: Difference between a proto-oncogene and an oncogene?
Answer: If one of these two is mutated the cell cycle goes too fast (pedal to the medal)
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Question: Difference between a mutated tumor suppressor gene allele versus two mutated tumor suppressor gene alleles?
Answer: If one is mutated the cell cycle is OK but if both are mutated the cell cycle wont function.
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Question: Name 2 types of cancer treatments and how they affect the body?
Answer: Chemotherapy-uses radiation to kill all cells but as well as it is killing the cancer cells it is also killing the good cells so the immune system decreases.
Immunotherapy- Is a treatment that uses the person immune system to fight off the cancer cells by stimulation to fight the cancer cells harder
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